Osteoadherin (OSAD), also known as Osteomodulin, is an extracellular matrix keratan sulfate proteoglycan that belongs to the class II subfamily of small leucine-rich proteoglycans (SLRP). LRR motifs consist of approximately 20‑30 amino acids (aa) with conserved leucine spacing, folded into a structure with one beta -sheet and one alpha -helix (1, 2).

Osteoadherin. Short name: OSAD.

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KSPG osteomodulin antibody; OSAD antibody. Osteoadherin antibody; Osteoadherin proteoglycan antibody; Osteomodulin antibody; SLRR2C antibody. Jan 1, 2019 Osteoadherin (also termed osteomodulin) is encoded by the Omd gene and is a keratan sulfate proteoglycan of the class II subfamily of SLRPs. Mar 30, 2020 localization indicating that this reactivity was due to another KS-proteoglycan, possibly osteoadherin. (osteomodulin) which has known roles in Human Osteoadherin/Osteomodulin quantitates human Osteoadherin/ Osteomodulin in serum, plasma, supernatant. The assay will exclusively recognize both Glycoproteins, such as alkaline phosphatase, osteonectin, RGD-containing proteins (osteoadherin, thrombospondin, fibronectin, vitronectin, osteopontin, bone Apr 18, 2018 Bone matrix proteins: isolation and characterization of a novel cell-binding keratan sulfate proteoglycan (Osteoadherin) from bovine bone.

*. Osteoadherin is a recently described bone proteoglycan containing keratan sulfate. It promotes integrin (α v β 3 )-mediated cell binding (Wendel, M., Sommarin, Y., and Heinegård, D. (1998) J. Cell Osteoadherin (OSAD), a keratan sulphate PG is a member of the small leucine-rich (SLRP) family of PGs and unlike other SLRPs, OSAD expression is restricted to mineralized tissues. It is proposed to have a high affinity for hydroxyapatite and has been shown to be expressed by mature osteoblasts but its exact role remains to be elucidated. Osteoadherin (OSAD), also known as Osteomodulin, is an extracellular matrix keratan sulfate proteoglycan that belongs to the class II subfamily of small leucine-rich proteoglycans (SLRP).

Quantitate human OMD in supernatant, serum and plasma. Sensitivity: 1.4 ng/mL Osteoadherin (OSAD) is a keratan sulfate proteoglycan recently isolated from bovine and rat bone.

Osteoadherin HDR Plasmid (h) is recommended for co-transfection with Osteoadherin CRISPR/Cas9 KO Plasmid (h) Osteoadherin HDR Plasmid (h) consists of a pool of 2-3 plasmids, each containing a homology-directed DNA repair (HDR) template corresponding to the cut sites generated by the Osteoadherin CRISPR/Cas9 KO Plasmid (h)

It was purified to homogeneity using a combination of ion-exchange chromatography, hydroxyapatite chromatography, and gel filtration. The Mr of the proteoglycan was 85,000 as determined by Osteoadherin, fibromodulin, and chondroadherin, which bind C1q and activate complement, were found to cause significantly higher C9 deposition in C4BP-depleted serum compared with Igs, indicating that the level of complement activation initiated by SLRPs is regulated by simultaneous binding to C4BP. Bovine osteoadherin contains leucine-rich repeats (LRRs) and is also rich in aspartic acid and glutamic acid. It had an apparent molecular mass of 85 kD under reducing conditions by SDS-PAGE.

Osteoadherin (OSAD), also known as Osteomodulin, is an extracellular matrix keratan sulfate proteoglycan that belongs to the class II subfamily of small leucine-rich proteoglycans (SLRP). LRR motifs consist of approximately 20‑30 amino acids (aa) with conserved leucine spacing, folded into a structure with one beta -sheet and one alpha -helix (1, 2).

27047 Ensembl ENSG00000127083 ENSMUSG00000048368 UniProt Q99983 O35103 RefSeq (mRNA) NM_005014 NM_012050 NM_001360708 RefSeq (protein) NP_005005 NP_036180 NP_001347637 Location (UCSC) Chr 9: 92.41 – 92.42 Mb Chr 13: 49.58 – 49.59 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Osteomodulin (also called osteoadherin or osteoadherin proteoglycan) is a protein that in humans is Listed are ELISA Kits for the detection of Osteoadherin, an alias name of osteomodulin. The human protein, encoded by the gene OMD, is 421 amino acid residues long and has a mass of 49,492 daltons.

Short name: OSAD.
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It promotes integrin (αvβ3)-mediated cell binding (Wendel, M., Sommarin, Y., and Heinegård, D. (1998) J. Cell Biol. 141, 839–847).

It is validated for Western Blot.
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Osteoadherin (also termed osteomodulin) is encoded by the Omd gene and is a keratan sulfate proteoglycan of the class II subfamily of SLRPs. Osteoadherin is highly expressed in mineralized tissues, including bone and dentin; however, it's precise roles remain unknown. Osteoadherin is a recently described bone proteoglycan containing keratan sulfate. It promotes integrin (α v β 3)-mediated cell binding (Wendel, M., Sommarin, Y., and Heinegård, D. (1998) J. Cell Biol.

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Osteoadherin (OSAD), also known as Osteomodulin, is an extracellular matrix keratan sulfate proteoglycan that belongs to the class II subfamily of small leucine-rich proteoglycans (SLRP). LRR motifs consist of approximately 20‑30 amino acids (aa) with conserved leucine spacing, folded into a structure with one beta -sheet and one alpha -helix (1, 2).

[Y Sommarin, M Wendel, Z Shen, U Hellman, D Heinegârd] PMID 9642227 .

Read "Osteoadherin is Upregulated by Mature Osteoblasts and Enhances Their InVitro Differentiation and Mineralization, Calcified Tissue International" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.

It promotes integrin (alphav beta3)-mediated cell binding (Wendel, M., Sommarin, Y., and Heinegârd, D. (1998) J. Cell Biol. 141, 839-847). The primary structure of bovine osteoadherin has now been determined by nucleo … 2019-10-18 · Osteoadherin (also termed osteomodulin) is encoded by the Omd gene and is a keratan sulfate proteoglycan of the class II subfamily of SLRPs. Osteoadherin is highly expressed in mineralized tissues, including bone and dentin; however, it's precise roles remain unknown.

The primary structure of bovine osteoadherin has now been determined by nucleotide sequencing of a cDNA clone 1997-05-01 Osteoadherin, a cell-binding keratan sulfate proteoglycan in bone, belongs to the family of leucine-rich repeat proteins of the extracellular matrix. [Y Sommarin, M Wendel, Z Shen, U Hellman, D Heinegârd] PMID 9642227 . Abstract Osteoadherin is a recently described bone … A small cell-binding proteoglycan for which we propose the name osteoadherin was extracted from bovine bone with guanidine hydrochloride–containing EDTA.